![]() Between the IRS and the outer root sheath (ORS) there is an unicellular layer known as “companion layer” (CL). The inner root sheath (IRS) also consists of three vertical strata that from the inside to the outside are the cuticle of the sheath, the Huxley’s layer and the Henle’s layer. The hair has three concentric layers from the inside to the outside: cortex, medulla and the cuticle of the hair or “epidermicule”. The matrix cells of the bulb, which are found in the germinative compartment, when multiply, thanks to the activation by the bulge cells, they form well-differentiated structures that correspond to the hair and to the inner root sheath. ![]() Follicle is composed in its distal portion by the bulb, which is formed by the hair matrix and papilla, and in the lateral wall, bottom up, by the bulge, which contains “follicular stem cells”, the sebaceous gland, and the apocrine sweat gland.
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